<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vitj</journal-id><journal-title-group><journal-title xml:lang="ru">Врач и информационные технологии</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Doctor and Information Technologies</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1811-0193</issn><issn pub-type="epub">2413-5208</issn><publisher><publisher-name>Pirogov National Medical and Surgical Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/18110193_2022_1_4</article-id><article-id custom-type="elpub" pub-id-type="custom">vitj-133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Применение методов математического моделирования для прогнозирования осложнений гипертонической болезни</article-title><trans-title-group xml:lang="en"><trans-title>Application of mathematical modeling for prediction of complications of hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туценко</surname><given-names>К. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Tutsenko</surname><given-names>K. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Туценко К.О.</p><p>г. Красноярск</p></bio><bio xml:lang="en"><p>Tutsenko K.O.</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">kseniamkib@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наркевич</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Narkevich</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наркевич А.Н., д.м.н.</p><p>г. Красноярск</p></bio><bio xml:lang="en"><p>Narkevich A.N., Dr. Sci. (Medicine)</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">narkevichart@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Россиев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rossiev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россиев Д.А., д.м.н., профессор</p><p>г. Красноярск</p></bio><bio xml:lang="en"><p>Rossiev D.A., Dr. Sci. (Medicine), Professor</p><p>Krasnoyarsk</p><p> </p></bio><email xlink:type="simple">rossiev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ипатюк</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ipatyuk</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ипатюк О.В.</p><p>г. Красноярск</p></bio><bio xml:lang="en"><p>Ipatyuk O.V.</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">s.v.b.07@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеев</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeev</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Авдеев С.М.</p><p>г. Красноярск</p></bio><bio xml:lang="en"><p>Avdeev S.M.</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">avdeev63@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University named after prof. V. F. Voino-Yasenetsky»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>УН «Пальмира»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>UN «Palmira»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ИП Авдеев Сергей Максимович</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Individual entrepreneur Avdeev Sergey Maksimovich</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>4</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Туценко К.О., Наркевич А.Н., Россиев Д.А., Ипатюк О.В., Авдеев С.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Туценко К.О., Наркевич А.Н., Россиев Д.А., Ипатюк О.В., Авдеев С.М.</copyright-holder><copyright-holder xml:lang="en">Tutsenko K.O., Narkevich A.N., Rossiev D.A., Ipatyuk O.V., Avdeev S.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vit-j.ru/jour/article/view/133">https://www.vit-j.ru/jour/article/view/133</self-uri><abstract><p>Гипертоническая болезнь является многофакторным заболеванием, при котором наблюдается повышение артериального давления. Избыточное давление может приводить к ишемической болезни сердца, инсульту, заболеваниям почек и другим патологиям. Частота осложнений гипертонической болезни во многом зависит от точности прогноза их развития. Врач, имея информацию о вероятности развития того или иного осложнения, может назначить пациенту соответствующую профилактику и снизить риск возникновения сердечно-сосудистого события. Для прогнозирования используются различные математические модели и компьютерные программы. Стандартные подходы к прогнозированию риска сердечно-сосудистых заболеваний имеют невысокую точность. В настоящее время всё чаще для подобных целей используются методы машинного обучения, которые имеют высокую прогностическую ценность для оценки риска развития осложнений гипертонической болезни. Данный обзор посвящён описанию многообразия методов, используемых для указанной цели.</p></abstract><trans-abstract xml:lang="en"><p>Hypertension is a complex cardiovascular condition, defined as an abnormally high blood pressure. Such long-term and consistent increase in blood pressure could result in coronary heart disease, stroke, kidney damage and other serious debilitating conditions. Complication rate from hypertension depends on how well you can predict and prevent those complications, considering individual patient’s risks. Several mathematical models and computer algorithms that are currently used for these purposes have relatively low accuracy and prognostic value. Machine learning methods could be a next step in improving outcomes of patients with hypertension in terms of calculating their individual risk of complications and choosing rational therapeutic strategy based on that data. We performed a literature review to cover the topic of machine learning methods in the management of patients with hypertension.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипертоническая болезнь</kwd><kwd>факторы риска</kwd><kwd>прогнозирование осложнений</kwd><kwd>машинное обучение</kwd><kwd>оценка риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>risk factors</kwd><kwd>prediction of complications</kwd><kwd>machine learning</kwd><kwd>risk rating</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Информационный бюллетень Всемирной организации здравоохранения. C. 17–24. https://www.who.int/ru/news-room/fact-sheets/detail/hypertension/</mixed-citation><mixed-citation xml:lang="en">World Health Organization: 17–24. (In Russ). https://www.who.int/ru/news-room/fact-sheets/detail/hypertension/</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Искаков Е.Б. Распространенность факторов риска развития сердечно-сосудистых заболеваний // Медицина и экология. — 2017. — №3(84).</mixed-citation><mixed-citation xml:lang="en">Iskakov YeB. Prevalence of risk factors of cardiovascular diseases. Medicine and ecology. 2017; 3 Leonov V.P., Shneider V.E. An example of using logistic regression to calculate the prediction of the initial operational investigation (84). (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Леонов В.П., Шнейдер В.Э. Пример использования логистической регрессии для расчета прогноза исхода оперативного лечения. http://www.biometrica.tomsk.ru/biometrica.tomsk.ru/logit_7.htm.</mixed-citation><mixed-citation xml:lang="en">Leonov VP, Shneider VE. An example of using logistic regression to calculate the prediction of the initial operational investigation. (In Russ). http://www.biometrica.tomsk.ru/biometrica.tomsk.ru/logit_7.htm.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ардашев В.Н., Фурсов А.Н., Конев А.В. и др. Прогнозирование развития инфаркта миокарда у больных гипертонической болезнью // Российский кардиологический журнал. — 2004. — №2. — С.11-15.</mixed-citation><mixed-citation xml:lang="en">Ardashev VN, Fursov AN, Konev AV, et al. Prognosing of myocardial infarction outcome in arterial hypertension patients. Russian Journal of Cardiology. 2004; 2: 11-15. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Суспицына И.Н., Сукманова И.А. Факторы риска и прогнозирование развития инфаркта миокарда у мужчин различных возрастных групп // Российский кардиологический журнал. — 2016. — №8(136). С. 58–63.</mixed-citation><mixed-citation xml:lang="en">Suspitsina IN, Sukmanova IA. Risk factors and prediction of miocardial infarction in males of different age. Russian Journal of Cardiology. 2016; 8(136): 58–63. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Голощапов-Аксёнов Р.С. Информативность факторов риска в прогнозировании инфаркта миокарда // Здравоохранение Российской Федерации. — 2019. — Т.63. — №2. – С. 60–65.</mixed-citation><mixed-citation xml:lang="en">Goloshchapov-Aksenov RS. Informativity of risk factors in forecasting myocardial infarction. Health care of the Russian Federation. 2019; 63(2): 60–65. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Яскевич Р.А. Применение методов математического моделирования в прогнозе тяжести клинического течения артериальной гипертонии у мужчин // Современные проблемы науки и образования. — 2016. — №6. — С.62.</mixed-citation><mixed-citation xml:lang="en">Yaskevich RA. Application of methods of mathematical modeling in the prediction of severity of clinical course of arterial hypertension in men. Modern Problems of Science and Education. 2016; 6: 62. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kawai T, Ohishi M, Ito N, et al. Alteration of vascular function is an important factor in the correlation between visit-to-visit blood pressure variability and cardiovascular disease. Journal of Hypertension. 2013; 31: 1387-1395.</mixed-citation><mixed-citation xml:lang="en">Kawai T, Ohishi M, Ito N, et al. Alteration of vascular function is an important factor in the correlation between visit-to-visit blood pressure variability and cardiovascular disease. Journal of Hypertension. 2013; 31: 1387-1395.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chi X, Wang X, Guo Z, et al. Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension. Artery Research. 2018; 24: 40-46.</mixed-citation><mixed-citation xml:lang="en">Chi X, Wang X, Guo Z, et al. Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension. Artery Research. 2018; 24: 40-46.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tao Y, Xu J, Song B, Xie X, et al. Short-term blood pressure variability and long-term blood pressure variability: which one is a reliable predictor for recurrent stroke. Journal of Human Hypertension. 2017; 31(9): 568-573.</mixed-citation><mixed-citation xml:lang="en">Tao Y, Xu J, Song B, Xie X, et al. Short-term blood pressure variability and long-term blood pressure variability: which one is a reliable predictor for recurrent stroke. Journal of Human Hypertension. 2017; 31(9): 568-573.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P, Saladini F, Mos L, et al. Short-term blood pressure variability outweighs average 24-h blood pressure in the prediction of cardiovascular events in hypertension of the young. Journal of Human Hypertension. 2019; 37(7: 1419-1426.</mixed-citation><mixed-citation xml:lang="en">Palatini P, Saladini F, Mos L, et al. Short-term blood pressure variability outweighs average 24-h blood pressure in the prediction of cardiovascular events in hypertension of the young. Journal of Human Hypertension. 2019; 37(7: 1419-1426.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mehlum MH, Liestøl K, Kjeldsen SE, et al. Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks. European Heart Journal. 2018; 39(24): 2243-2251.</mixed-citation><mixed-citation xml:lang="en">Mehlum MH, Liestøl K, Kjeldsen SE, et al. Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks. European Heart Journal. 2018; 39(24): 2243-2251.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Arashi H, Ogawa H, Yamaguchi J, Kawada-Watanabe E, Hagiwara N. Impact of visit-to-visit variability and systolic blood pressure control on subsequent outcomes in hypertensive patients with coronary artery disease (from the HIJ-CREATE substudy). American Journal of Cardiology. 2015; 116(2): 236-42.</mixed-citation><mixed-citation xml:lang="en">Arashi H, Ogawa H, Yamaguchi J, Kawada-Watanabe E, Hagiwara N. Impact of visit-to-visit variability and systolic blood pressure control on subsequent outcomes in hypertensive patients with coronary artery disease (from the HIJ-CREATE substudy). American Journal of Cardiology. 2015; 116(2): 236-42.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen TW, Thijs L, Li Y, Boggia J, et al. International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators. Prognostic value of reading to-reading blood pressure variability over 24 h in 8938 subjects from 11 populations // Hypertension. 2010; 55: 10491057.</mixed-citation><mixed-citation xml:lang="en">Hansen TW, Thijs L, Li Y, Boggia J, et al. International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators. Prognostic value of reading to-reading blood pressure variability over 24 h in 8938 subjects from 11 populations // Hypertension. 2010; 55: 10491057.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ayala Solares JR, Canoy D, Raimondi FED, et al. Long-Term Exposure to Elevated Systolic Blood Pressure in Predicting Incident Cardiovascular Disease: Evidence From Large-Scale Routine Electronic Health Records. Journal of the American Heart Association. 2019; 8(12): e012129.</mixed-citation><mixed-citation xml:lang="en">Ayala Solares JR, Canoy D, Raimondi FED, et al. Long-Term Exposure to Elevated Systolic Blood Pressure in Predicting Incident Cardiovascular Disease: Evidence From Large-Scale Routine Electronic Health Records. Journal of the American Heart Association. 2019; 8(12): e012129.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Adamsson Eryd S, Gudbjörnsdottir S, Manhem K, et al. Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort study. British Medical Journal. 2016; 354: i4070.</mixed-citation><mixed-citation xml:lang="en">Adamsson Eryd S, Gudbjörnsdottir S, Manhem K, et al. Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort study. British Medical Journal. 2016; 354: i4070.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Мартыненко А.М., Давыдова А.В. Изменения АДФ-агрегации тромбоцитов и фатальные осложнения у больных гипертонической болезнью // Международный студенческий научный вестник. — 2017. — №6. — С.1.</mixed-citation><mixed-citation xml:lang="en">Martynenko AM, Davydova AV. Changes of ADP-platelet aggregation and fatal complications in hypertensive patients. International student scientific bulletin. 2017; 6: 1. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Huang S, Xie X, Sun Y, et al. Development of a nomogram that predicts the risk for coronary atherosclerotic heart disease. Aging. 2020; 12(10): 9427. – 39.</mixed-citation><mixed-citation xml:lang="en">Huang S, Xie X, Sun Y, et al. Development of a nomogram that predicts the risk for coronary atherosclerotic heart disease. Aging. 2020; 12(10): 9427. – 39.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ambale-Venkatesh B, Yang X, Wu CO, et al. Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circulation Research. 2017; 121(9): 1092-1101.</mixed-citation><mixed-citation xml:lang="en">Ambale-Venkatesh B, Yang X, Wu CO, et al. Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circulation Research. 2017; 121(9): 1092-1101.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Weng SF, Reps J, Kai J, Garibaldi JM, Qureshi N. Can machine-learning improve cardiovascular risk prediction using routine clinical data? Public Library of Science One. 2017; 12(4): e0174944.</mixed-citation><mixed-citation xml:lang="en">Weng SF, Reps J, Kai J, Garibaldi JM, Qureshi N. Can machine-learning improve cardiovascular risk prediction using routine clinical data? Public Library of Science One. 2017; 12(4): e0174944.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dimopoulos AC, Nikolaidou M, Caballero FF, et al. Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. BMC Medical Research Methodology. 2018; 18(1): 179.</mixed-citation><mixed-citation xml:lang="en">Dimopoulos AC, Nikolaidou M, Caballero FF, et al. Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. BMC Medical Research Methodology. 2018; 18(1): 179.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Groenhof TKJ, Rittersma ZH, Bots ML, Brandjes M, Jacobs JJL, Grobbee DE, et. al. A computerised decision support system for cardiovascular risk management ‘live’ in the electronic health record environment: development, validation and implementation-the Utrecht Cardiovascular Cohort Initiative. Netherlands Heart Journal. 2019; 27(9): 435-442.</mixed-citation><mixed-citation xml:lang="en">Groenhof TKJ, Rittersma ZH, Bots ML, Brandjes M, Jacobs JJL, Grobbee DE, et. al. A computerised decision support system for cardiovascular risk management ‘live’ in the electronic health record environment: development, validation and implementation-the Utrecht Cardiovascular Cohort Initiative. Netherlands Heart Journal. 2019; 27(9): 435-442.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Du Z, Yang Y, Zheng J, et al. Accurate prediction of coronary heart disease for patients with hypertension from electronic health records with big data and machine-learning methods: model development and performance evaluation. Journal of Medical Internet Research Medical Informatics. 2020; 8(7): е17257.</mixed-citation><mixed-citation xml:lang="en">Du Z, Yang Y, Zheng J, et al. Accurate prediction of coronary heart disease for patients with hypertension from electronic health records with big data and machine-learning methods: model development and performance evaluation. Journal of Medical Internet Research Medical Informatics. 2020; 8(7): е17257.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mandair D, Tiwari P, Simon S, Colborn KL, Rosenberg MA. Prediction of incident myocardial infarction using machine learning applied to harmonized electronic health record data. BMC medical informatics and decision making. 2020; 20(1): 1-10.</mixed-citation><mixed-citation xml:lang="en">Mandair D, Tiwari P, Simon S, Colborn KL, Rosenberg MA. Prediction of incident myocardial infarction using machine learning applied to harmonized electronic health record data. BMC medical informatics and decision making. 2020; 20(1): 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y, Fang Y. Stroke Prediction with Machine Learning Methods among Older Chinese. International Journal of Environmental Research and Public Health. 2020; 17(6): 1828.</mixed-citation><mixed-citation xml:lang="en">Wu Y, Fang Y. Stroke Prediction with Machine Learning Methods among Older Chinese. International Journal of Environmental Research and Public Health. 2020; 17(6): 1828.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Мамаев А.Н., Кудлай Д.А. Статистические методы в медицине. // Практическая медицина. — 2021.</mixed-citation><mixed-citation xml:lang="en">Mamaev AN, Kudlay D.. Statistical methods in medicine. Practical medicine. 2021. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев А.В., Добриднюк С.Л. Искусственный интеллект в медицине и здравоохранении // Информационное общество. — 2017. — №4-5. — С.78-93.</mixed-citation><mixed-citation xml:lang="en">Gusev AV, Dobridniuk SL. Artificial intelligence in medicine and healthcare. Information Society. 2017; 4-5: 78–93. (In Russ).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
