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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vitj</journal-id><journal-title-group><journal-title xml:lang="ru">Врач и информационные технологии</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Doctor and Information Technologies</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1811-0193</issn><issn pub-type="epub">2413-5208</issn><publisher><publisher-name>Pirogov National Medical and Surgical Center</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/18110193_2022_2_4</article-id><article-id custom-type="elpub" pub-id-type="custom">vitj-123</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ РЕДАКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EDITORIAL</subject></subj-group></article-categories><title-group><article-title>Прозрачный искусственный интеллект для медицины</article-title><trans-title-group xml:lang="en"><trans-title>Explainable artificial intelligence for medicine</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>О. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>академик РАН, д.м.н., профессор</p><p>Москва</p></bio><bio xml:lang="en"><p>Academician of the RAS, Dr. Sci. (Medicine), Professor</p><p>Moscow</p></bio><email xlink:type="simple">nmhc@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андриков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Andrikov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.т.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>PhD</p><p>Moscow</p></bio><email xlink:type="simple">andrikovda@immersmed.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максименко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimenko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.ф.м.н.</p><p>г. Казань</p></bio><bio xml:lang="en"><p>Dr. Sci.</p><p>Kazan</p></bio><email xlink:type="simple">maximenkovl@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Храмов</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Hramov</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.ф.м.н., профессор</p><p>г. Калининград</p></bio><bio xml:lang="en"><p>Dr. Sci., Professor</p><p>Kaliningrad</p></bio><email xlink:type="simple">hramovae@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медико-хирургический Центр имени Н.И. Пирогова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Medical and Surgical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Иммерсмед»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Immersmed LLC</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Университет Иннополис</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Innopolis University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Балтийский федеральный университет им. И. Канта</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Immanuel Kant Baltic Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>4</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпов О.Э., Андриков Д.А., Максименко В.А., Храмов А.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Карпов О.Э., Андриков Д.А., Максименко В.А., Храмов А.Е.</copyright-holder><copyright-holder xml:lang="en">Karpov O.E., Andrikov D.A., Maksimenko V.A., Hramov A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vit-j.ru/jour/article/view/123">https://www.vit-j.ru/jour/article/view/123</self-uri><abstract><p>Успех и массовое применение современных технологий искусственного интеллекта (ИИ) и, в частности, методов глубокого обучения нейронных сетей привели нас к четкому пониманию двух основных проблем: проблемы ошибок (проблема надежности) и проблемы явного объяснения решений, принимаемых ИИ (проблема прозрачности). Эти проблемы тесно связаны между собой: необъяснимые ошибки ИИ могут повторяться снова и снова. Это совершенно неприемлемо с точки зрения применения ИИ в здравоохранении, потому что является критичным для жизни и здоровья пациентов. Если оставить проблемы ошибок и объяснимости нерешенными, то непрозрачность решений ИИ может привести к отказу или существенному ограничению от использования систем ИИ в задачах медицины. В данном комментарии мы обсуждаем проблемы прозрачного объяснимого интеллекта для медицины и рассматриваем различные подходы к их решению.</p></abstract><trans-abstract xml:lang="en"><p>The success and wide-range applications of artificial intelligence (AI) technologies and, in particular, deep learning neural networks methods have led us to a clear understanding of two main problems: the problem of errors (the reliability problem) and the problem of explicitly explaining the decisions made by AI (the explanability problem). These problems are closely related: unexplained AI errors can happen again and again. This is completely unacceptable from the perspective of AI applications in health care because it is critical to the lives and health of patients. If left unresolved, the problems of error and explainability can lead to the rejection or significant restriction of AI systems in medical applications. In this paper, we discuss the problems of explainable artificial intelligence (XAI) for medicine and consider different approaches to solving them.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>цифровые медицинские технологии</kwd><kwd>биомаркер</kwd><kwd>нейроинтерфейс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>artificial intelligence</kwd><kwd>digital healthcare</kwd><kwd>biomarker</kwd><kwd>neurointerface</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа поддержана Президентским грантом (проект НШ-589.2022.1.2).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">CB Insights Research. Healthcare remains the hottest AI category for deals. April 12, 2017. [Last accessed on 2022 Feb 11]. Available at: https://www.cbinsights.com/research/artificial-intelligence-healthcare-startups-investors.</mixed-citation><mixed-citation xml:lang="en">CB Insights Research. Healthcare remains the hottest AI category for deals. April 12, 2017. [Last accessed on 2022 Feb 11]. Available at: https://www.cbinsights.com/research/artificial-intelligence-healthcare-startups-investors.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">На основе данных State of AI Q3’21. [Last accessed on 2022 March 22]. Available at: https:// www.cbinsights.com/research/report/ai-trends-q3-2021.</mixed-citation><mixed-citation xml:lang="en">На основе данных State of AI Q3’21. [Last accessed on 2022 March 22]. Available at: https://www.cbinsights.com/research/report/ai-trends-q3-2021.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nature medicine. 2019; 25(1): 30-36.</mixed-citation><mixed-citation xml:lang="en">He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nature medicine. 2019; 25(1): 30-36.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson Kevin B, et al. Precision medicine, AI, and the future of personalized health care. Clinical and translational science. 2021;14(1): 86-93.</mixed-citation><mixed-citation xml:lang="en">Johnson Kevin B, et al. Precision medicine, AI, and the future of personalized health care. Clinical and translational science. 2021;14(1): 86-93.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Карпов О.Э., Храмов А.Е. Прогностическая медицина // Врач и информационные технологии. — 2021. — №3. — С.20-37. doi: 10.25881/18110193_2021_3_20.</mixed-citation><mixed-citation xml:lang="en">Karpov OE, Hramov AE. Prognosticheskaya medicina. Vrach i informacionnye tekhnologii. 2021; 3: 20-37. (In Russ). doi: 10.25881/18110193_2021_3_20.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Strabo K, Tavel JA. What are biomarkers? Current Opinion in HIV and AIDS. 2010; 5(6): 463.</mixed-citation><mixed-citation xml:lang="en">Strabo K, Tavel JA. What are biomarkers? Current Opinion in HIV and AIDS. 2010; 5(6): 463.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Toprol E.J. Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. Basic Books, New York, NY, 2019.</mixed-citation><mixed-citation xml:lang="en">Toprol E.J. Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. Basic Books, New York, NY, 2019.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kundu S. AI in medicine must be explainable. Nature Medicine. 2021; 27(8): 1328.</mixed-citation><mixed-citation xml:lang="en">Kundu S. AI in medicine must be explainable. Nature Medicine. 2021; 27(8): 1328.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ashby WR. An Introduction to Cybernetics. Chapman &amp; Hall Ltd., London, UK, 1957.</mixed-citation><mixed-citation xml:lang="en">Ashby WR. An Introduction to Cybernetics. Chapman &amp; Hall Ltd., London, UK, 1957.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Friedman CP. A «fundamental theorem» of biomedical informatics. J. Am. Med. Inform. Assoc. 2009; 16: 169-170.</mixed-citation><mixed-citation xml:lang="en">Friedman CP. A «fundamental theorem» of biomedical informatics. J. Am. Med. Inform. Assoc. 2009; 16: 169-170.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Karpov OE, Grubov VV, Maksimenko VA, Utaschev N, Semerikov VE, Andrikov DA, Hramov AE. Noise amplification precedes extreme epileptic events on human EEG. Physical Review E. 2021; 103: 022310.</mixed-citation><mixed-citation xml:lang="en">Karpov OE, Grubov VV, Maksimenko VA, Utaschev N, Semerikov VE, Andrikov DA, Hramov AE. Noise amplification precedes extreme epileptic events on human EEG. Physical Review E. 2021; 103: 022310.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Perera P, Patel VM. Learning deep features for one-class classification. IEEE Transactions on Image Processing. 2019; 28(11): 5450-5463.</mixed-citation><mixed-citation xml:lang="en">Perera P, Patel VM. Learning deep features for one-class classification. IEEE Transactions on Image Processing. 2019; 28(11): 5450-5463.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Кучин А.С., Грубов В.В., Максименко В.А., Утяшев Н.П. Автоматизированное рабочее место врача эпилептолога с возможностью автоматического поиска приступов эпилепсии // Врач и информационные технологии. — 2021. — №3. — С.62-73. doi: 1025881/18110193_2021_3_62.</mixed-citation><mixed-citation xml:lang="en">Kuchin AS, Grubov VV, Maksimenko VA, Utyashev NP. Avtomatizirovannoe rabochee mesto vracha epileptologa s vozmozhnost’yu avtomaticheskogo poiska pristupov epilepsii. Vrach i informacionnye tekhnologii. 2021; 3: 62-73. (In Russ). doi: 1025881/18110193_2021_3_62.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhary U, Birbaumer N, Ramos-Murguialday A. Brain–computer interfaces for communication and rehabilitation. Nature Reviews Neurology. 2016; 12(9): 513-525.</mixed-citation><mixed-citation xml:lang="en">Chaudhary U, Birbaumer N, Ramos-Murguialday A. Brain–computer interfaces for communication and rehabilitation. Nature Reviews Neurology. 2016; 12(9): 513-525.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shah RB, Patel M, Maahs DM, Shah V N. Insulin delivery methods: Past, present and future. International journal of pharmaceutical investigation. 2016; 6(1): 1.</mixed-citation><mixed-citation xml:lang="en">Shah RB, Patel M, Maahs DM, Shah V N. Insulin delivery methods: Past, present and future. International journal of pharmaceutical investigation. 2016; 6(1): 1.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ricci RP, Morichelli L, Santini M. Home monitoring remote control of pacemaker and implantable cardioverter defibrillator patients in clinical practice: impact on medical management and health-care resource utilization. Europace. 2008; 10(2): 164-170.</mixed-citation><mixed-citation xml:lang="en">Ricci RP, Morichelli L, Santini M. Home monitoring remote control of pacemaker and implantable cardioverter defibrillator patients in clinical practice: impact on medical management and health-care resource utilization. Europace. 2008; 10(2): 164-170.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hramov AE, Maksimenko VA, Pisarchik AN. Physical principles of brain–computer interfaces and their applications for rehabilitation, robotics and control of human brain states. Physics Reports. 2021; 918: 1-133.</mixed-citation><mixed-citation xml:lang="en">Hramov AE, Maksimenko VA, Pisarchik AN. Physical principles of brain–computer interfaces and their applications for rehabilitation, robotics and control of human brain states. Physics Reports. 2021; 918: 1-133.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkisova K, van Luijtelaar G. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depressiony. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011; 35(4): 854-876.</mixed-citation><mixed-citation xml:lang="en">Sarkisova K, van Luijtelaar G. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depressiony. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011; 35(4): 854-876.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">van Luijtelaar G, Lüttjohann A, Makarov VV, Maksimenko VA, Koronovskii AA, Hramov AE. Methods of automated absence seizure detection, interference by stimulation, and possibilities for prediction in genetic absence models. Journal of Neuroscience Methods. 2016; 260: 144-158.</mixed-citation><mixed-citation xml:lang="en">van Luijtelaar G, Lüttjohann A, Makarov VV, Maksimenko VA, Koronovskii AA, Hramov AE. Methods of automated absence seizure detection, interference by stimulation, and possibilities for prediction in genetic absence models. Journal of Neuroscience Methods. 2016; 260: 144-158.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Мaksimenko VA, Heukelum S, Makarov VV, Kelderhuis J, Lüttjohann A, Koronovskii AA, Hramov AE, Luijtelaar G. Absence Seizure Control by a Brain Computer Interface. Scientific Reports. 2017; 7: 2487.</mixed-citation><mixed-citation xml:lang="en">Мaksimenko VA, Heukelum S, Makarov VV, Kelderhuis J, Lüttjohann A, Koronovskii AA, Hramov AE, Luijtelaar G. Absence Seizure Control by a Brain Computer Interface. Scientific Reports. 2017; 7: 2487.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Budde B, Maksimenko V, Sarink K, Seidenbecher T, van Luijtelaar G, Hahn T, Pape HC, Lüttjohann Seizure prediction in genetic rat models of absence epilepsy: improved performance through multiple-site cortico-thalamic recordings combined with machine learning. Eneuro. 2022; 9(1).</mixed-citation><mixed-citation xml:lang="en">Budde B, Maksimenko V, Sarink K, Seidenbecher T, van Luijtelaar G, Hahn T, Pape HC, Lüttjohann Seizure prediction in genetic rat models of absence epilepsy: improved performance through multiple-site cortico-thalamic recordings combined with machine learning. Eneuro. 2022; 9(1).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
